SCHEMBL30878477

SCHEMBL30878477

C#Cc1cc(=O)n(-c2ccc(NC(=O)C3CC3)cc2)c2nc(Nc3ccccc3OC)ncc12

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
EGFR P00533 16/20 0.51
ROS1 P08922 1/20 0.51
ALK Q9UM73 1/20 0.51
MAP4K1 Q92918 2/20 0.47
BTK Q06187 1/20 0.46
AKT3 Q9Y243 1/20 0.46
JAK3 P52333 1/20 0.46
TTK P33981 1/20 0.46
FLT3 P36888 1/20 0.46
BLK P51451 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30878308 0.91 FLT3 (0.52) EGFRMAP4K1BTKAKT3JAK3
SCHEMBL30878486 0.90 FLT3 (0.51) EGFRROS1ALKMAP4K1BTK
SCHEMBL30878811 0.89 EGFR (0.48) EGFRROS1ALKMAP4K1BTK
SCHEMBL30878392 0.88 BTK (0.61) EGFRBTKJAK3FLT3BLK
SCHEMBL30878470 0.86 MAP4K1 (0.55) EGFRMAP4K1BTKJAK3
SCHEMBL30879348 0.85 MAPK3 (0.49) EGFRMAP4K1BTKJAK3TTK
SCHEMBL30878437 0.85 MAP4K1 (0.54) EGFRMAP4K1BTKFLT3BLK
SCHEMBL30878482 0.84 MAP4K1 (0.52) EGFRMAP4K1BTKFLT3BLK
SCHEMBL30878336 0.84 FLT3 (0.51) EGFRMAP4K1BTKFLT3
SCHEMBL30878340 0.83 BTK (0.58) EGFRBTKAKT3JAK3TTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP claimed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO claimed
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO disclosed