Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | CDK4 | P11802 | 7/20 | 0.32 |
| ▸ | CCND1 | P24385 | 6/20 | 0.32 |
| ▸ | CCND3 | P30281 | 5/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | CCND2 | P30279 | 2/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 2/20 | 0.30 |
| ▸ | CDK9 | P50750 | 2/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878729 | 0.91 | JAK2 (0.39) | JAK2JAK1TTKCDK4CCND1 | |
| SCHEMBL30878702 | 0.83 | TTK (0.40) | JAK2JAK1TTKCDK4CCND1 | |
| SCHEMBL30878929 | 0.77 | USP19 (0.31) | TTKPIM1PIM2 | |
| SCHEMBL30878713 | 0.77 | CDK4 (0.38) | JAK2JAK1TTKCDK4CCND1 | |
| SCHEMBL22553579 | 0.76 | CDK4 (0.43) | JAK2JAK1CDK4CCND1CCND3 | |
| SCHEMBL22553578 | 0.76 | CDK4 (0.43) | JAK2JAK1CDK4CCND1CCND3 | |
| SCHEMBL30878785 | 0.76 | TTK (0.42) | JAK1TTKCDK4CCND1CCND3 | |
| SCHEMBL30879078 | 0.75 | TTK (0.43) | JAK2JAK1TTKMAPK8MAPK9 | |
| SCHEMBL30878965 | 0.74 | TTK (0.37) | JAK2JAK1TTKMAPK8MAPK9 | |
| SCHEMBL30879312 | 0.73 | TTK (0.36) | JAK2JAK1TTKMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |