USP19 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15046621	0.37	13/20
SCHEMBL16498194	0.34	7/20
SCHEMBL16498196	0.34	7/20
SCHEMBL1915968	0.34	7/20
SCHEMBL1915971	0.34	7/20
SCHEMBL17868433	0.60	6/20
SCHEMBL17868434	0.60	6/20
SCHEMBL14735439	0.56	6/20
SCHEMBL17276037	0.46	6/20
SCHEMBL13041227	0.34	6/20
SCHEMBL1916462	0.32	6/20
SCHEMBL1916466	0.32	6/20
SCHEMBL14735338	0.54	5/20
SCHEMBL17868542	0.54	5/20
SCHEMBL17868543	0.54	5/20
SCHEMBL14735378	0.54	5/20
Trifluoroacetic Acid (SCHEMBL17869191)	0.51	5/20
SCHEMBL3975707	0.47	5/20
SCHEMBL7749807	0.46	5/20
SCHEMBL1916232	0.32	5/20

Clinical trials — most relevant to USP19 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Androgen Ablation Therapy With or Without Chemotherapy in Treating Patients With Metastatic Prostate Cancer	PHASE3	COMPLETED
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma	PHASE2	WITHDRAWN
Relapsed and/or Refractory Non-Hodgkin Lymphoma Study	PHASE2	WITHDRAWN
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes	PHASE2	UNKNOWN
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy	PHASE2	NOT_YET_RECRUITING
Phase II Study of Vandetanib in Individuals With Kidney Cancer	PHASE2	COMPLETED
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck	PHASE1	COMPLETED
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome	nan	RECRUITING
The Danish TURNER Cryopreservation Study	nan	RECRUITING
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Clinical Trial of Levodopa/Carbidopa ( Sinemet) Therapy in Angel Man Syndrome	nan	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Long Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1	nan	RECRUITING
Mobilization of CD34+ Peripheral Blood Stem Cells in Patients With Diamond Blackfan Anemia Syndrome (DBAS)	nan	RECRUITING
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
PHF19 Gene Expression and EZH2 Gene Deletion in Acute Myeloid Leukemia	nan	UNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors	nan	NOT_YET_RECRUITING
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS	nan	COMPLETED
X-Linked Hypohidrotic Ectodermal Dysplasia (XLHED) Carrier Outlook Toward Reproduction Survey	nan	COMPLETED
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome	nan	RECRUITING
Stakeholders of Rare Diseases Informing Values In Neuroethics	nan	RECRUITING
Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit	nan	COMPLETED
Relationship Between Nutritional State and Respiratory Muscle Weakness in Adult Patients With Bronchietasis	nan	UNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a USP19 binder may also engage these)

Protein	Name	Similarity
Q3UJD6	—	1.000	Q3UJD6 →
Q9UPV7	—	0.999	Q9UPV7 →
Q9Z0E3	—	0.998	Q9Z0E3 →
Q9NYI0	—	0.997	Q9NYI0 →
Q5DW34	—	0.997	Q5DW34 →
Q8BLR5	—	0.996	Q8BLR5 →
Q3UIZ8	—	0.996	Q3UIZ8 →
Q9Z1J2	—	0.995	Q9Z1J2 →
F1MJR8	—	0.995	F1MJR8 →
Q6J1Y9	—	0.995	Q6J1Y9 →
E9Q555	—	0.995	E9Q555 →
P10244	—	0.994	P10244 →
Q6P1I6	—	0.994	Q6P1I6 →
Q5BIR3	—	0.994	Q5BIR3 →
O89084	—	0.994	O89084 →
Q9Z2U2	—	0.994	Q9Z2U2 →
Q9Y426	—	0.994	Q9Y426 →
Q80UE6	—	0.994	Q80UE6 →
Q8BZ21	—	0.994	Q8BZ21 →
Q63553	—	0.994	Q63553 →
Q76N89	—	0.994	Q76N89 →
Q80TT8	—	0.994	Q80TT8 →
Q2PFD7	—	0.994	Q2PFD7 →
Q4R739	—	0.994	Q4R739 →
Q99PI4	—	0.994	Q99PI4 →
Q8BWQ5	—	0.994	Q8BWQ5 →
Q2TAC6	—	0.994	Q2TAC6 →
Q6A037	—	0.993	Q6A037 →
Q5SW75	—	0.993	Q5SW75 →
O00273	—	0.993	O00273 →