SCHEMBL30879036

SCHEMBL30879036

CC(C)[Si](C#Cc1cc(=O)n(-c2ccccc2)c2nc(Nc3ccc4c(c3)CCNCC4)ncc12)(C(C)C)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
WEE1 P30291 19/20 0.47
BTK Q06187 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30878296 0.86 BTK (0.48) WEE1BTK
SCHEMBL30879080 0.85 BTK (0.47) WEE1BTK
SCHEMBL30878921 0.84 JAK2 (0.46) WEE1BTK
SCHEMBL30878717 0.84 CDK4 (0.54) WEE1
SCHEMBL30878950 0.82 MAP4K1 (0.43) WEE1BTK
SCHEMBL30878988 0.81 CCND3 (0.51) WEE1
SCHEMBL30878983 0.81 FLT3 (0.55) BTK
SCHEMBL30879031 0.81 WEE1 (0.48) WEE1
SCHEMBL30878824 0.80 CDK4 (0.45) WEE1
SCHEMBL30879189 0.80 CDK4 (0.52) WEE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO disclosed