Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | BRD2 | P25440 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.44 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 8/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 7/20 | 0.41 |
| ▸ | CCND2 | P30279 | 7/20 | 0.41 |
| ▸ | CCND3 | P30281 | 7/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879031 | 0.91 | WEE1 (0.48) | JAK2BRD4JAK3CSF1RCDK4 | |
| SCHEMBL30878402 | 0.86 | BTK (0.49) | BTKCAMK2DJAK2BRD4JAK1 | |
| SCHEMBL30879036 | 0.85 | WEE1 (0.47) | BTKWEE1 | |
| SCHEMBL30878717 | 0.85 | CDK4 (0.54) | CDK4CDK6CCND1CCND2CCND3 | |
| SCHEMBL30879161 | 0.84 | CCND3 (0.48) | BTKJAK2BRD4JAK3CDK4 | |
| SCHEMBL30878824 | 0.83 | CDK4 (0.45) | CDK4CDK6CCND1CCND2CCND3 | |
| SCHEMBL30878988 | 0.82 | CCND3 (0.51) | BRD4CDK4CDK6CCND1CCND2 | |
| SCHEMBL30879056 | 0.82 | CDK4 (0.47) | BTKJAK2BRD4JAK1BRD2 | |
| SCHEMBL30878950 | 0.81 | MAP4K1 (0.43) | BTKCAMK2DJAK2JAK1JAK3 | |
| SCHEMBL30879189 | 0.81 | CDK4 (0.52) | JAK3CSF1RCDK4CDK6CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |