Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 7/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 9/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878844 | 0.87 | JAK1 (0.42) | JAK1PIK3CAMTORPRKDCJAK2 | |
| SCHEMBL30879079 | 0.85 | JAK1 (0.40) | JAK1PIK3CAMTORPRKDCJAK2 | |
| SCHEMBL1226673 | 0.85 | CYP1A2 (0.37) | CDK4CCND1CCND2CCND3TTK | |
| SCHEMBL30878735 | 0.84 | JAK1 (0.38) | JAK1PIK3CAMTORPRKDCJAK2 | |
| SCHEMBL30878784 | 0.81 | CDK4 (0.41) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL1226546 | 0.81 | CDK4 (0.41) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL28385150 | 0.79 | CDK4 (0.49) | JAK1PIK3CAMTORPRKDCJAK2 | |
| SCHEMBL29785353 | 0.79 | CDK4 (0.49) | JAK1PIK3CAMTORPRKDCJAK2 | |
| SCHEMBL20674043 | 0.79 | CDK4 (0.49) | JAK1PIK3CAMTORPRKDCJAK2 | |
| SCHEMBL30879102 | 0.77 | FKBP1A (0.33) | CDK4CCND1CCND2CCND3TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |