SCHEMBL30879063

SCHEMBL30879063

CC(C)[Si](C#Cc1cc(=O)n(C2CCC(CO)CC2)c2nc(Nc3ccc(N(C)CCN(C)C)cc3)ncc12)(C(C)C)C(C)C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 3/20 0.52
CDK9 P50750 3/20 0.52
EGFR P00533 1/20 0.44
CDK4 P11802 17/20 0.43
CCND1 P24385 17/20 0.43
CCND3 P30281 15/20 0.41
CCND2 P30279 14/20 0.41
NUAK1 O60285 2/20 0.40
FGFR1 P11362 1/20 0.40
FGFR2 P21802 1/20 0.40
FGFR4 P22455 1/20 0.40
FGFR3 P22607 1/20 0.40
MARK3 P27448 1/20 0.39
MARK2 Q7KZI7 1/20 0.39
MARK4 Q96L34 1/20 0.39
NUAK2 Q9H093 1/20 0.39
MARK1 Q9P0L2 1/20 0.39
CCNB2 O95067 1/20 0.39
CDK1 P06493 1/20 0.39
CCNB1 P14635 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30878842 0.90 CCNT1 (0.53) CCNT1CDK9EGFRCDK4CCND1
SCHEMBL30878383 0.89 CCNT1 (0.56) CCNT1CDK9EGFRCDK4CCND1
SCHEMBL30879283 0.84 CCNT1 (0.45) CCNT1CDK9EGFRCDK4CCND1
SCHEMBL30878964 0.84 CCNT1 (0.51) CCNT1CDK9EGFRCDK4CCND1
SCHEMBL30879096 0.80 EGFR (0.45) CCNT1CDK9EGFRCDK4CCND1
SCHEMBL30878411 0.78 CCNT1 (0.58) CCNT1CDK9EGFRCDK4CCND1
SCHEMBL30879204 0.77 TTK (0.54) EGFRCDK4CCND1CCND3CCND2
SCHEMBL30878884 0.76 TTK (0.53) CDK4CCND1CCND3CCND2NUAK1
SCHEMBL30879273 0.76 EGFR (0.39) CCNT1CDK9EGFRCDK4CCND1
SCHEMBL30879043 0.76 EGFR (0.40) CCNT1CDK9EGFRCDK4CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO disclosed