SCHEMBL30879283

SCHEMBL30879283

CC(C)[Si](C#Cc1cc(=O)n(C)c2nc(Nc3ccc(N(C)CCN(C)C)cc3)ncc12)(C(C)C)C(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 2/20 0.45
CDK9 P50750 2/20 0.45
CDK4 P11802 6/20 0.45
CCND1 P24385 6/20 0.45
FGFR4 P22455 1/20 0.43
EGFR P00533 3/20 0.41
CCND2 P30279 5/20 0.40
CCND3 P30281 5/20 0.40
WEE1 P30291 4/20 0.40
FGFR1 P11362 2/20 0.39
JAK3 P52333 1/20 0.37
MEN1 O00255 1/20 0.37
USP2 O75604 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
TSHR P16473 1/20 0.37
MAPK1 P28482 1/20 0.37
CYP2C19 P33261 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30879273 0.91 EGFR (0.39) CCNT1CDK9CDK4CCND1FGFR4
SCHEMBL30879096 0.89 EGFR (0.45) CCNT1CDK9CDK4CCND1FGFR4
SCHEMBL30878876 0.88 CDK4 (0.54) CDK4CCND1FGFR4EGFRCCND2
SCHEMBL30878822 0.86 EGFR (0.49) CDK4CCND1FGFR4EGFRFGFR1
SCHEMBL30878368 0.86 CCNT1 (0.49) CCNT1CDK9CDK4CCND1FGFR4
SCHEMBL30879063 0.84 CCNT1 (0.52) CCNT1CDK9CDK4CCND1FGFR4
SCHEMBL30879043 0.84 EGFR (0.40) CCNT1CDK9CDK4CCND1FGFR4
SCHEMBL30879251 0.84 FGFR4 (0.46) CCNT1CDK9CDK4CCND1FGFR4
SCHEMBL30879345 0.83 CHEK1 (0.36) CCNT1CDK9CDK4CCND1EGFR
SCHEMBL30879314 0.83 CCNT1 (0.44) CCNT1CDK9CDK4CCND1FGFR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO disclosed