Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.42 |
| ▸ | SKP1 | P63208 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879016 | 0.87 | ALDH1A1 (0.52) | MERTKBTKSYK | |
| SCHEMBL16415194 | 0.87 | MERTK (0.41) | MERTKBTKCKS1BSKP1SKP2 | |
| SCHEMBL15249748 | 0.86 | SYK (0.51) | MERTKPDE4BSYKPPARG | |
| SCHEMBL16202740 | 0.85 | MERTK (0.49) | MERTKBTKCKS1BSKP1SKP2 | |
| SCHEMBL30878946 | 0.85 | MERTK (0.46) | MERTKBTKCKS1BSKP1SKP2 | |
| SCHEMBL26931042 | 0.82 | MERTK (0.57) | MERTKSYKPPARG | |
| SCHEMBL26931049 | 0.82 | MERTK (0.57) | MERTKSYKPPARG | |
| SCHEMBL16415196 | 0.82 | PDE4B (0.39) | MERTKBTKCKS1BSKP1SKP2 | |
| SCHEMBL1226594 | 0.81 | MEN1 (0.49) | MERTKSYKPPARG | |
| SCHEMBL26161013 | 0.81 | SYK (0.49) | MERTKSYKPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |