Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.59 |
| ▸ | EGFR | P00533 | 9/20 | 0.59 |
| ▸ | WEE1 | P30291 | 5/20 | 0.54 |
| ▸ | USP2 | O75604 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | CASP1 | P29466 | 3/20 | 0.50 |
| ▸ | CASP7 | P55210 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878861 | 0.90 | WEE1 (0.67) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL30878366 | 0.89 | FGFR1 (0.66) | FGFR1EGFRWEE1USP2CYP1A2 | |
| SCHEMBL30878805 | 0.87 | EGFR (0.56) | FGFR1EGFRWEE1SRCLCK | |
| SCHEMBL30879263 | 0.87 | ABL1 (0.59) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL30879194 | 0.82 | WEE1 (0.62) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL30878742 | 0.81 | SRC (0.58) | FGFR1WEE1CYP3A4SRCFGFR2 | |
| SCHEMBL30878753 | 0.81 | SRC (0.58) | FGFR1WEE1CYP3A4SRCFGFR2 | |
| SCHEMBL30878358 | 0.81 | FGFR1 (0.64) | FGFR1EGFRWEE1USP2CYP1A2 | |
| SCHEMBL30878665 | 0.80 | WEE1 (0.49) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL30879233 | 0.80 | WEE1 (0.52) | FGFR1EGFRWEE1SRCFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |