Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 10/20 | 0.59 |
| ▸ | SRC | P12931 | 9/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.59 |
| ▸ | EGFR | P00533 | 6/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.59 |
| ▸ | KIT | P10721 | 2/20 | 0.59 |
| ▸ | WEE1 | P30291 | 8/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | STK25 | O00506 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878932 | 0.93 | ABL1 (0.62) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878311 | 0.89 | SRC (0.67) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878861 | 0.89 | WEE1 (0.67) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30879136 | 0.87 | FGFR1 (0.59) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878456 | 0.81 | ABL1 (0.70) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878459 | 0.81 | ABL1 (0.65) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878665 | 0.81 | WEE1 (0.49) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30879233 | 0.81 | WEE1 (0.52) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878805 | 0.80 | EGFR (0.56) | SRCEGFRFGFR1WEE1LCK | |
| SCHEMBL30878753 | 0.80 | SRC (0.58) | SRCPDGFRBPDGFRAFGFR1WEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |