Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 10/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 5/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | CCND1 | P24385 | 1/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.50 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878349 | 0.87 | TTK (0.59) | TTKEGFR | |
| SCHEMBL30879172 | 0.86 | CDK4 (0.56) | EGFRCDK4CCND1CDK6 | |
| SCHEMBL30878821 | 0.85 | EGFR (0.47) | ALKEGFRINSRIGF1RLRRK2 | |
| SCHEMBL30879244 | 0.84 | FLT3 (0.54) | TTKALKEGFRBRD4 | |
| SCHEMBL30878685 | 0.82 | IGF1R (0.54) | ALKEGFRINSRIGF1RDCLK1 | |
| SCHEMBL30879220 | 0.80 | CSF1R (0.38) | EGFRCDK4CCND1BRD4 | |
| SCHEMBL30878822 | 0.80 | EGFR (0.49) | TTKALKEGFRIGF1RCDK4 | |
| SCHEMBL20080169 | 0.79 | EGFR (0.69) | TTKALKEGFRINSRIGF1R | |
| SCHEMBL30879403 | 0.79 | CDK4 (0.63) | EGFRCDK4CCND1 | |
| SCHEMBL30879021 | 0.77 | TNK2 (0.48) | TTKEGFRCDK4CCND1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |