Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.53 |
| ▸ | INSR | P06213 | 3/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.51 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.50 |
| ▸ | DCLK2 | Q8N568 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878354 | 0.90 | IGF1R (0.60) | IGF1RTNK2SRCEGFRALK | |
| SCHEMBL30878805 | 0.88 | EGFR (0.56) | IGF1RSRCEGFRALKPTK2 | |
| SCHEMBL30878742 | 0.87 | SRC (0.58) | SRCALK | |
| SCHEMBL30878753 | 0.87 | SRC (0.58) | SRCALK | |
| SCHEMBL30878322 | 0.83 | EGFR (0.59) | IGF1RTNK2SRCEGFRALK | |
| SCHEMBL30879162 | 0.83 | EGFR (0.48) | IGF1RTNK2EGFRALKINSR | |
| SCHEMBL30879192 | 0.82 | TTK (0.54) | IGF1REGFRALKINSRDCLK1 | |
| SCHEMBL30879136 | 0.79 | FGFR1 (0.59) | TNK2SRCEGFRALKLRRK2 | |
| SCHEMBL30878861 | 0.79 | WEE1 (0.67) | SRCEGFR | |
| SCHEMBL30878745 | 0.77 | FGFR1 (0.58) | SRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |