Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.38 |
| ▸ | STK4 | Q13043 | 2/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879626 | 0.86 | MAP4K1 (0.56) | MAP4K1NTRK1MAP4K2STK4 | |
| SCHEMBL21296075 | 0.86 | MAP4K1 (0.56) | MAP4K1NTRK1MAP4K2STK4 | |
| SCHEMBL320207 | 0.85 | KDM4E (0.47) | PIM1PIM3PIM2TYK2MAP4K1 | |
| SCHEMBL9081101 | 0.80 | ADORA3 (0.43) | PIM1PIM2SCN9A | |
| SCHEMBL13727555 | 0.79 | PARP1 (0.42) | PIM1NTRK1SCN9A | |
| SCHEMBL16505347 | 0.75 | GRM2 (0.40) | PIM1PIM2NTRK1GRM2SCN9A | |
| SCHEMBL2543831 | 0.75 | HDAC6 (0.50) | NTRK1SCN9A | |
| SCHEMBL29383595 | 0.75 | HDAC6 (0.50) | NTRK1SCN9A | |
| SCHEMBL14892024 | 0.73 | PIM2 (0.46) | PIM1PIM3PIM2GRM2 | |
| SCHEMBL29470045 | 0.73 | PIM2 (0.46) | PIM1PIM3PIM2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112292380-B | N- (phenyl) -2- (phenyl) pyrimidine-4-carboxamide derivatives and related compounds as HPK1 inhibitors for the treatment of cancer | 因赛特公司 | 2024-04-05 | — | — | CN | claimed |
| CN-112292380-B | N- (phenyl) -2- (phenyl) pyrimidine-4-carboxamide derivatives and related compounds as HPK1 inhibitors for the treatment of cancer | 因赛特公司 | 2024-04-05 | — | — | CN | disclosed |