SCHEMBL30880684

SCHEMBL30880684

COc1cc(N)cc(-c2ccnn2C)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
CYP19A1 P11511 1/20 0.43
PIK3CD O00329 1/20 0.43
PIK3CA P42336 1/20 0.43
PIK3CB P42338 1/20 0.43
PI4KA P42356 1/20 0.43
PIK3CG P48736 1/20 0.43
PI4KB Q9UBF8 1/20 0.43
ICMT O60725 1/20 0.40
NTRK1 P04629 1/20 0.38
KCNH2 Q12809 1/20 0.37
HRH3 Q9Y5N1 1/20 0.37
ALDH1A1 P00352 4/20 0.37
BRD4 O60885 1/20 0.37
BRD3 Q15059 1/20 0.37
COMT P21964 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29487862 0.89 CYP1A2 (0.49) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL4827059 0.76 CYP1A2 (0.63) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL980384 0.73 PIK3CD (0.50) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL15652106 0.73 ALDH1A1 (0.59) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL30839799 0.73 ALDH1A1 (0.50) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL27185954 0.73 ALDH1A1 (0.50) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL28234703 0.72 KDM4E (0.47) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL16826278 0.72 CYP3A4 (0.53) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL18483005 0.72 COMT (0.46) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL27975555 0.72 BRD4 (0.50) CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024078513-A1 CONDENSED AZINES FOR TREATING CANCER CHENGDU ANTICANCER BIOSCIENCE , LTD. (CN) 2024-04-18 WO disclosed