Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 13/20 | 0.56 |
| ▸ | JAK2 | O60674 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5391597 | 1.00 | PDPK1 (0.56) | PDPK1JAK2GAAKDM4ECYP3A4 | |
| Hydrochloric Acid SCHEMBL7425346 | 0.98 | PDPK1 (0.55) | PDPK1JAK2GAAKDM4ECYP3A4 | |
| SCHEMBL27623383 | 0.86 | JAK2 (0.68) | PDPK1JAK2ROCK1FGFR1FGFR2 | |
| SCHEMBL7214708 | 0.85 | JAK2 (0.56) | PDPK1JAK2GAAKDM4ECYP3A4 | |
| SCHEMBL2144862 | 0.83 | PDPK1 (0.59) | PDPK1JAK2GAAKDM4ECYP3A4 | |
| SCHEMBL91579 | 0.83 | PDPK1 (0.55) | PDPK1JAK2GAAKDM4ECYP3A4 | |
| Hydrochloric Acid SCHEMBL7214665 | 0.83 | JAK2 (0.55) | PDPK1JAK2GAAKDM4ECYP3A4 | |
| SCHEMBL12124008 | 0.81 | GAA (0.43) | PDPK1JAK2GAAROCK1PKM | |
| SCHEMBL7220524 | 0.81 | GAA (0.43) | PDPK1JAK2GAAROCK1PKM | |
| SCHEMBL26977245 | 0.80 | PDPK1 (0.51) | PDPK1JAK2GAAKDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119350433-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-112867706-B | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118373875-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-07-23 | — | — | CN | disclosed |
| CN-117964684-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-117964683-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2024-05-03 | — | — | CN | disclosed |