Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.54 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | CLK3 | P49761 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 3/20 | 0.38 |
| ▸ | CCND1 | P24385 | 3/20 | 0.38 |
| ▸ | CCND3 | P30281 | 3/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21522732 | 1.00 | DYRK1A (0.54) | DYRK1ACSNK1ECLK1CLK2CLK3 | |
| SCHEMBL16084172 | 0.81 | GSK3B (0.42) | DYRK1ACSNK1ECLK1CLK2CLK3 | |
| SCHEMBL21539259 | 0.75 | CDK4 (0.56) | DYRK1ACSNK1ECLK1CLK2CLK3 | |
| SCHEMBL31113441 | 0.75 | DYRK1A (0.43) | DYRK1ACLK1DYRK2ALDH1A1MAPT | |
| SCHEMBL25149020 | 0.75 | DYRK1A (0.43) | DYRK1ACLK1DYRK2ALDH1A1MAPT | |
| SCHEMBL20740567 | 0.74 | CDK5 (0.42) | DYRK1ACSNK1ECLK1CLK2CLK3 | |
| SCHEMBL25149682 | 0.71 | KDM4E (0.41) | DYRK1ACSNK1ECLK1CLK2CLK3 | |
| SCHEMBL1106498 | 0.71 | CSNK1E (0.47) | DYRK1ACSNK1ECLK1CLK2CLK3 | |
| SCHEMBL20508523 | 0.70 | DYRK1A (1.00) | DYRK1ACSNK1ECLK1CLK2CLK3 | |
| SCHEMBL25149382 | 0.70 | DYRK1A (0.58) | DYRK1ACSNK1ECLK1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676931-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF | BioSplice Therapeutics, Inc. (US) | 2026-01-14 | — | — | EP | disclosed |
| WO-2024211797-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF | BIOSPLICE THERAPEUTICS, INC. (US) | 2024-10-10 | — | — | WO | disclosed |
| CN-118286225-A | 2-Amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors | 辉瑞公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-112313219-B | 2-Amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors | 辉瑞公司 | 2024-04-26 | — | — | CN | disclosed |