Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK3 | P49761 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 7/20 | 0.36 |
| ▸ | CDK4 | P11802 | 4/20 | 0.35 |
| ▸ | CCND1 | P24385 | 3/20 | 0.35 |
| ▸ | CCND3 | P30281 | 3/20 | 0.35 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20740512 | 0.82 | CDK6 (0.53) | CDK5DYRK1ACDK5R1CSNK1ECLK1 | |
| SCHEMBL17168772 | 0.79 | ADORA2B (0.34) | PIK3CAMTORALDH1A1SMN1; SMN2 | |
| SCHEMBL22190717 | 0.77 | CYP1A2 (0.39) | CLK4CDK4CCND1CCND3ALDH1A1 | |
| SCHEMBL21927511 | 0.74 | CDK5 (0.45) | CDK5DYRK1ACDK5R1CSNK1ECLK1 | |
| SCHEMBL30888949 | 0.74 | DYRK1A (0.54) | CDK5DYRK1ACDK5R1CSNK1ECLK1 | |
| SCHEMBL21522732 | 0.74 | DYRK1A (0.54) | CDK5DYRK1ACDK5R1CSNK1ECLK1 | |
| SCHEMBL10316608 | 0.70 | CDK1 (0.50) | CDK5EGFRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1496411 | 0.70 | CDK2 (0.46) | CDK5DYRK1ACDK5R1ALDH1A1CCNA2 | |
| SCHEMBL20740530 | 0.69 | CSNK1E (0.35) | CDK5DYRK1ACDK5R1CSNK1ECLK1 | |
| SCHEMBL18830089 | 0.69 | MET (0.39) | CDK5DYRK1ACDK5R1CLK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3444246-B1 | 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF | SHANGHAI XUNHE PHARMACEUTICAL TECH CO LTD (CN) | 2019-11-06 | — | — | EP | disclosed |
| US-10464927-B2 | 2,4-disubstituted pyrimidines as CDK inhibitors | Shanghai Xunhe Pharmaceutical Technology Co. Ltd. (CN) | 2019-11-05 | — | — | US | disclosed |
| CN-107286134-B | 2,4- disubstituted pyrimidines derivatives are as CDK inhibitor and its application | 上海勋和医药科技有限公司 | 2019-04-12 | — | — | CN | disclosed |
| US-20190071427-A1 | 2,4-Disubstituted Pyrimidine Derivative as CDK Inhibitor and Use Thereof | CHENGDU JINRUI FOUNDATION BIOTECH CO., LTD. (CN) | 2019-03-07 | — | — | US | disclosed |
| EP-3444246-A1 | 2,4-DISUBSTITUTED PYRIMIDINE DERIVATIVE AS CDK INHIBITOR AND USE THEREOF | Shanghai Xunhe Pharmaceutical Technology Co., Ltd. (CN) | 2019-02-20 | — | — | EP | disclosed |
| CN-107286134-A | 2,4- disubstituted pyrimidines derivatives are used as CDK inhibitor and its application | 上海勋和医药科技有限公司 | 2017-10-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190071427-A1 | 2,4-Disubstituted Pyrimidine Derivative as CDK Inhibitor and Use Thereof | CDK4, CDK2, CDK6 | CDK5 15/4885DYRK1A 955/4885CDK5R1 45/4885 |
| US-10464927-B2 | 2,4-disubstituted pyrimidines as CDK inhibitors | CDK4, CDK2, CDK6 | CDK5 15/4885DYRK1A 870/4885CDK5R1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.