Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23885303 | 0.75 | KMT2A (0.40) | TLR7KMT2AKDM4EALDH1A1 | |
| SCHEMBL18486834 | 0.75 | TLR7 (0.41) | TLR7HSP90AA1ADORA2AADORA1KDM4E | |
| SCHEMBL20182182 | 0.73 | DYRK1A (0.32) | TLR7ADORA2AADORA1ADORA2BDYRK1A | |
| SCHEMBL18484787 | 0.72 | ADORA2A (0.41) | TLR7MEN1KMT2AADORA2AADORA1 | |
| SCHEMBL19684529 | 0.72 | HRH4 (0.42) | TLR7ADORA2AADORA1ALDH1A1ADORA2B | |
| SCHEMBL20162817 | 0.71 | DYRK1A (0.33) | TLR7DYRK1A | |
| SCHEMBL19711588 | 0.70 | ADORA1 (0.35) | TLR7ADORA2AADORA1ALDH1A1ADORA2B | |
| SCHEMBL23885335 | 0.69 | HDAC6 (0.38) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL18026004 | 0.68 | TLR7 (0.35) | TLR7ADORA2AADORA1 | |
| SCHEMBL784138 | 0.68 | CDK1 (0.36) | TLR7ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4424311-A2 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation (US) | 2024-09-04 | — | — | EP | disclosed |
| EP-3541390-B1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUND (US) | 2024-05-01 | — | — | EP | disclosed |