Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162817 | 0.85 | DYRK1A (0.33) | DYRK1ATLR7 | |
| SCHEMBL20182350 | 0.82 | HSP90AA1 (0.34) | — | |
| SCHEMBL20182247 | 0.79 | ADK (0.44) | DYRK1AADORA2AADORA1 | |
| SCHEMBL30892149 | 0.73 | TLR7 (0.33) | DYRK1ATLR7ADORA2AADORA1ADORA2B | |
| SCHEMBL20162922 | 0.71 | HSP90AA1 (0.31) | — | |
| SCHEMBL28402007 | 0.70 | EP300 (0.37) | ADORA2B | |
| SCHEMBL20181888 | 0.67 | ADK (0.44) | ADORA2B | |
| SCHEMBL24015557 | 0.61 | — | — | |
| SCHEMBL21183232 | 0.60 | DYRK1A (0.38) | DYRK1ATLR7ADORA2AADORA1 | |
| SCHEMBL23042852 | 0.59 | ADORA2A (0.37) | DYRK1ATLR7ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |