⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3089224 | 1.00 | — | — | |
| SCHEMBL1852318 | 1.00 | — | — | |
| SCHEMBL13889158 | 1.00 | — | — | |
| SCHEMBL13888941 | 0.96 | TSHR (0.64) | — | |
| SCHEMBL15484298 | 0.96 | TSHR (0.64) | — | |
| SCHEMBL15337087 | 0.96 | TSHR (0.64) | — | |
| SCHEMBL11056265 | 0.96 | TSHR (0.77) | — | |
| SCHEMBL10795387 | 0.96 | TSHR (0.64) | — | |
| SCHEMBL13889159 | 0.96 | TSHR (0.64) | — | |
| SCHEMBL2154470 | 0.96 | TSHR (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368983-A1 | CONTROLLING FOR TAGMENTATION SEQUENCING LIBRARY INSERT SIZE USING ARCHAEAL HISTONE-LIKE PROTEINS | KAPA BIOSYSTEMS INC (US) | 2025-12-04 | — | — | US | disclosed |
| EP-4581153-A1 | IMPROVEMENTS TO NEXT-GENERATION TARGET ENRICHMENT PERFORMANCE | F. Hoffmann-La Roche AG (CH) | 2025-07-09 | — | — | EP | disclosed |
| EP-4547839-A1 | CONTROLLING FOR TAGMENTATION SEQUENCING LIBRARY INSERT SIZE USING ARCHAEAL HISTONE-LIKE PROTEINS | Kapa Biosystems, Inc. (US) | 2025-05-07 | — | — | EP | disclosed |
| CN-119895049-A | Improvements to next generation target enrichment performance | 豪夫迈·罗氏有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119497755-A | Control of library insert size for fragmentation and tag sequencing using archaebacteria histone-like proteins | 卡帕生物系统公司 | 2025-02-21 | — | — | CN | disclosed |
| WO-2024046992-A1 | IMPROVEMENTS TO NEXT-GENERATION TARGET ENRICHMENT PERFORMANCE | F. HOFFMANN-LA ROCHE AG (CH) | 2024-03-07 | — | — | WO | disclosed |
| WO-2024003332-A1 | CONTROLLING FOR TAGMENTATION SEQUENCING LIBRARY INSERT SIZE USING ARCHAEAL HISTONE-LIKE PROTEINS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-01-04 | — | — | WO | disclosed |
| CN-115184120-A | Fixative composition for cell-containing liquid samples | 凯杰有限公司 | 2022-10-14 | — | — | CN | disclosed |
| EP-3149446-B1 | FIXATIVE COMPOSITION FOR CELL-COMPRISING LIQUID SAMPLES | QIAGEN GMBH (DE) | 2022-07-06 | — | — | EP | disclosed |
| US-10794803-B2 | Fixative composition for cell-comprising liquid samples and methods and kit thereof | QIAGEN GMBH (DE) | 2020-10-06 | — | — | US | disclosed |
| EP-3149446-A1 | FIXATIVE COMPOSITION FOR CELL-COMPRISING LIQUID SAMPLES | Qiagen GmbH (DE) | 2017-04-05 | — | — | EP | disclosed |
| US-20170052095-A1 | Fixative Composition for Cell-Comprising Liquid Samples | QIAGEN GMBH (DE) | 2017-02-23 | — | — | US | disclosed |
| EP-2126542-B1 | FIXATION OF A BIOLOGICAL MATERIAL | QIAGEN GMBH (DE) | 2016-11-02 | — | — | EP | disclosed |
| WO-2015181220-A1 | FIXATIVE COMPOSITION FOR CELL-COMPRISING LIQUID SAMPLES | QIAGEN GMBH (DE) | 2015-12-03 | — | — | WO | disclosed |
| US-8796028-B2 | Method for treating a biological sample with a composition containing at least one polyol and excluding water | QIAGEN GMBH (DE) | 2014-08-05 | — | — | US | disclosed |
| US-20100173295-A1 | FIXATION OF A BIOLOGICAL MATERIAL | QIAGEN GMBH (DE) | 2010-07-08 | — | — | US | disclosed |
| US-20100009349-A1 | Method for Treating a Biological Sample | QIAGEN GMBH (DE) | 2010-01-14 | — | — | US | disclosed |
| EP-1965190-A1 | Fixation of a biological sample | Qiagen GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |