Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13157897 | 1.00 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AMAPK1TSHRCNR2 | |
| SCHEMBL3092598 | 0.88 | PTK2 (0.53) | SMN1; SMN2RAB9AMAPK1ALDH1A1MEN1 | |
| SCHEMBL13157941 | 0.88 | PTK2 (0.53) | SMN1; SMN2RAB9AMAPK1ALDH1A1MEN1 | |
| SCHEMBL13157898 | 0.86 | GRIN2B (0.59) | SMN1; SMN2RAB9AMAPK1TSHRCNR2 | |
| SCHEMBL1257910 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9AMAPK1CNR2ALDH1A1 | |
| SCHEMBL6372084 | 0.86 | SMN1; SMN2 (0.55) | SMN1; SMN2RAB9AMAPK1CNR2ALDH1A1 | |
| SCHEMBL3109744 | 0.86 | GRIN2B (0.59) | SMN1; SMN2RAB9AMAPK1TSHRCNR2 | |
| SCHEMBL3105142 | 0.85 | POLB (0.55) | ALDH1A1GAAMEN1KMT2ASLC18A3 | |
| SCHEMBL13157795 | 0.85 | POLB (0.55) | ALDH1A1GAAMEN1KMT2ASLC18A3 | |
| SCHEMBL13158203 | 0.85 | POLB (0.55) | ALDH1A1GAAMEN1KMT2ASLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399455-B2 | Compounds useful as chemokine receptor antagonists | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-03-19 | — | — | US | disclosed |
| US-20100234356-A1 | COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234356-A1 | COMPOUNDS USEFUL AS CHEMOKINE RECEPTOR ANTAGONISTS | ACKR3, CCR5, CXCR2 | SMN1; SMN2 4691/4885RAB9A 1334/4885MAPK1 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.