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SCHEMBL30893186

SCHEMBL30893186

CC(C)(C)OC(=O)NCCCCN1CCC(NC(=O)COc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 10/20 0.59
▸ DDB1 Q16531 6/20 0.59
▸ STAT3 P40763 1/20 0.42
▸ BRD9 Q9H8M2 2/20 0.42
▸ LRRK2 Q5S007 1/20 0.41
▸ GSPT1 P15170 1/20 0.41
▸ IRAK4 Q9NWZ3 4/20 0.41
▸ TRIM24 O15164 2/20 0.40
▸ BTK Q06187 1/20 0.40
▸ AR P10275 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30893196 0.94 CRBN (0.55) CRBNDDB1STAT3BRD9LRRK2
SCHEMBL23705538 0.88 CRBN (0.57) CRBNDDB1LRRK2IRAK4BTK
SCHEMBL30058679 0.88 CRBN (0.57) CRBNDDB1LRRK2IRAK4BTK
SCHEMBL29617100 0.86 CRBN (0.59) CRBNDDB1LRRK2IRAK4AR
SCHEMBL23729950 0.86 CRBN (0.59) CRBNDDB1LRRK2IRAK4AR
SCHEMBL29617105 0.86 CRBN (0.59) CRBNDDB1LRRK2IRAK4AR
SCHEMBL30378605 0.85 CRBN (0.71) CRBNDDB1STAT3
SCHEMBL23317936 0.85 CRBN (0.71) CRBNDDB1STAT3
SCHEMBL30893300 0.85 CRBN (0.53) CRBNDDB1BRD9GSPT1
SCHEMBL23729668 0.83 CRBN (0.75) CRBNDDB1STAT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024097948-A1 DEGRADERS OF MDM2 AND USES THEREOF ROIVANT DISCOVERY, INC. (US) 2024-05-10 — — WO disclosed