Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | PDE8B | O95263 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 3/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PDE8A | O60658 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6270232 | 0.98 | CDK1 (0.53) | CDK1ADORA1ADORA2APDE8BCYP1A2 | |
| SCHEMBL7738505 | 0.81 | CDK1 (0.60) | CDK1ADORA1ADORA2APDE8BPI4KA | |
| SCHEMBL7438827 | 0.76 | PI4KA (0.52) | ADORA2APDE8BPKMPI4KAPI4K2B | |
| SCHEMBL232039 | 0.75 | ADORA2A (0.55) | CDK1ADORA1ADORA2APDE8BCYP1A2 | |
| SCHEMBL6270235 | 0.75 | CDK1 (0.47) | CDK1ADORA1ADORA2A | |
| SCHEMBL9233825 | 0.75 | CDK1 (0.47) | CDK1ADORA1ADORA2A | |
| SCHEMBL15354448 | 0.75 | CDK2 (0.63) | CDK1ADORA1ADORA2APDE8BPI4KA | |
| SCHEMBL15354446 | 0.75 | CDK1 (0.63) | CDK1ADORA1ADORA2APDE8BPI4KA | |
| SCHEMBL28126184 | 0.75 | PDE8B (0.35) | PDE8B | |
| SCHEMBL9482601 | 0.74 | PDE8B (0.45) | PDE8B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383759-B1 | N6 SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | DISCOVERY THERAPEUTICS INC (US) | 1998-09-09 | — | — | EP | claimed |
| EP-0457773-A1 | N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | WHITBY RESEARCH, Inc. (US) | 1991-11-27 | — | — | EP | claimed |
| WO-1990009178-A1 | N6-SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | WHITBY RESEARCH, INC. (US) | 1990-08-23 | — | — | WO | claimed |
| US-7795427-B2 | Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass | NEW YORK UNIVERSITY (US) | 2010-09-14 | — | — | US | disclosed |
| US-20070191279-A1 | Methods and compositions for treating disorders associated with increased bone turnover and osteopenia | CRONSTEIN BRUCE N | 2007-08-16 | — | — | US | disclosed |
| EP-0778836-B1 | SUBSTITUTED 9-ALKYLADENINES | ADERIS PHARMACEUTICALS INC (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1602657-A2 | Substituted 9-alkyladenines | Discovery Therapeutics, Inc. (US) | 2005-12-07 | — | — | EP | disclosed |
| EP-0880353-A4 | COMPOSITIONS AND METHODS FOR MODULATING MELANIN PRODUCTION | THERASYS INC (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-1999031101-A1 | ADENOSINE RECEPTOR ANTAGONISTS WITH IMPROVED BIOACTIVITY | UNIVERSITY OF SOUTH FLORIDA (US) | 1999-06-24 | — | — | WO | disclosed |
| EP-0880353-A1 | COMPOSITIONS AND METHODS FOR MODULATING MELANIN PRODUCTION | Therasys, Inc. (US) | 1998-12-02 | — | — | EP | disclosed |
| EP-0383759-B1 | N6 SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | DISCOVERY THERAPEUTICS INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0778836-A4 | SUBSTITUTED 9-ALKYLADENINES | DISCOVERY THERAPEUTICS INC (US) | 1998-02-04 | — | — | EP | disclosed |
| EP-0778836-A1 | SUBSTITUTED 9-ALKYLADENINES | Discovery Therapeutics, Inc. (US) | 1997-06-18 | — | — | EP | disclosed |
| WO-1996006845-A1 | SUBSTITUTED 9-ALKYLADENINES | DISCOVERY THERAPEUTICS, INC. (US) | 1996-03-07 | — | — | WO | disclosed |
| EP-0383759-A4 | N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | — | 1993-03-17 | — | — | EP | disclosed |
| EP-0457773-A4 | N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | — | 1993-03-10 | — | — | EP | disclosed |
| EP-0457773-A1 | N?6 -SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | WHITBY RESEARCH, Inc. (US) | 1991-11-27 | — | — | EP | disclosed |
| EP-0383759-A1 | N6 SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | Whitby Research Incorporated (US) | 1990-08-29 | — | — | EP | disclosed |
| WO-1990009178-A1 | N6-SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | WHITBY RESEARCH, INC. (US) | 1990-08-23 | — | — | WO | disclosed |
| WO-1988008303-A1 | N6-SUBSTITUTED 9-METHYLADENINES: A NEW CLASS OF ADENOSINE RECEPTOR ANTAGONISTS | NELSON RESEARCH AND DEVELOPMENT COMPANY (US) | 1988-11-03 | — | — | WO | disclosed |