Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20120643 | 0.74 | KDM4C (0.40) | GRM5KDM4CL3MBTL1RORCDHFR | |
| SCHEMBL29547563 | 0.74 | KDM4C (0.40) | GRM5KDM4CL3MBTL1RORCDHFR | |
| SCHEMBL20213850 | 0.74 | KDM4C (0.40) | GRM5KDM4CL3MBTL1RORCDHFR | |
| SCHEMBL30740345 | 0.74 | GRM5 (0.46) | GRM5KDM4CL3MBTL1RORCNPC1 | |
| SCHEMBL5643328 | 0.74 | POLB (0.44) | GRM5RORCHTR1AS1PR5MEN1 | |
| SCHEMBL29067795 | 0.72 | KDM4C (0.40) | GRM5KDM4CL3MBTL1RORCDHFR | |
| SCHEMBL1979487 | 0.71 | CCR5 (0.45) | KDM4CL3MBTL1CCR5PTGER1KDM1A | |
| SCHEMBL1980978 | 0.71 | CCR5 (0.38) | KDM4CL3MBTL1CCR5PTGER1KDM1A | |
| SCHEMBL4317561 | 0.71 | GRM5 (0.42) | GRM5KDM4CL3MBTL1RORCDHFR | |
| SCHEMBL14735919 | 0.71 | CCR5 (0.40) | KDM4CL3MBTL1CCR5PTGER1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612153-A1 | PREPARATION OF PYRAZOLOPYRIDINE AND TRIAZOLOPYRIDINE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024097576-A1 | PREPARATION OF PYRAZOLOPYRIDINE AND TRIAZOLOPYRIDINE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-05-10 | — | — | WO | disclosed |