Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31613163 | 0.77 | DYRK1A (0.42) | DYRK1ANFATC1CCNCCDK8MAPK1 | |
| SCHEMBL30896471 | 0.77 | ADORA2A (0.41) | DYRK1ANFATC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL28912013 | 0.74 | CA12 (0.46) | BRD4MAPTALDH1A1MAPK1 | |
| SCHEMBL6589213 | 0.74 | BRD4 (0.44) | RAB9ANPC1BRD4MAPTSMN1; SMN2 | |
| SCHEMBL30690121 | 0.74 | TSHR (0.44) | BRD4MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL25282000 | 0.74 | BRD4 (0.42) | BRD4MAPTALDH1A1ERN1 | |
| SCHEMBL30896402 | 0.74 | BRD4 (0.42) | BRD4MAPTALDH1A1ERN1 | |
| SCHEMBL30896325 | 0.72 | MAPT (0.44) | MAPTSMN1; SMN2MEN1ALDH1A1HTT | |
| SCHEMBL30690118 | 0.71 | BRD4 (0.45) | BRD4MAPTALDH1A1HTTKMT2A | |
| SCHEMBL28551101 | 0.71 | BRD4 (0.44) | RAB9ANPC1BRD4MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612128-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF HEMOGLOBINOPATHIES | Bristol-Myers Squibb Company (US) | 2025-09-10 | — | — | EP | disclosed |
| CN-120129677-A | Compounds and their use for the treatment of heme lesions | 百时美施贵宝公司 | 2025-06-10 | — | — | CN | disclosed |
| WO-2024097932-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF HEMOGLOBINOPATHIES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-05-10 | — | — | WO | disclosed |