Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 7/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24576877 | 1.00 | IKBKE (0.40) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL29760101 | 0.95 | IKBKE (0.39) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL24579082 | 0.95 | IKBKE (0.39) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL29760069 | 0.94 | IKBKE (0.40) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL30897451 | 0.94 | WNT1 (0.38) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL24577321 | 0.94 | WNT1 (0.38) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL24577185 | 0.91 | IKBKE (0.39) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL29760142 | 0.91 | IKBKE (0.39) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL30897453 | 0.91 | IKBKE (0.39) | IKBKETBK1WNT1GSK3BDYRK1A | |
| SCHEMBL24579086 | 0.91 | IKBKE (0.39) | IKBKETBK1WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2024-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | PDGFRA, PDGFRB, ABL1 | IKBKE 1365/4885TBK1 1176/4885WNT1 2716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.