Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azathioprine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.98 |
| ▸ | HBB | P68871 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | TP53 | P04637 | 2/20 | 0.98 |
| ▸ | GMNN | O75496 | 1/20 | 0.98 |
| ▸ | PGR | P06401 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azathioprine SCHEMBL29693611 | 0.99 | MAPT (1.00) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL4278 | 0.99 | MAPT (1.00) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL4436347 | 0.99 | MAPT (1.00) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL26152 | 0.98 | MAPT (0.98) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL317904 | 0.98 | MAPT (0.98) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL502599 | 0.98 | MAPT (0.98) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL4259183 | 0.91 | MAPT (0.84) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL8511946 | 0.90 | MAPT (0.82) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL8354969 | 0.90 | MAPT (0.82) | MAPTHBBLMNATP53GMNN | |
| Azathioprine SCHEMBL2328735 | 0.90 | MAPT (0.82) | MAPTHBBLMNATP53GMNN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799937-B2 | Metal coordinated compositions | SYNTHONICS, INC. (US) | 2010-09-21 | — | — | US | disclosed |
| US-20080015352-A1 | Metal coordinated compositions | HTERT3, INC. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015352-A1 | Metal coordinated compositions | SLC30A6, SLC39A7, SLC39A14 | MAPT 1357/4885HBB 1919/4885LMNA 4261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.