Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azathioprine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.84 |
| ▸ | HBB | P68871 | 2/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | GMNN | O75496 | 1/20 | 0.84 |
| ▸ | TP53 | P04637 | 1/20 | 0.84 |
| ▸ | PGR | P06401 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.84 |
| ▸ | BLM | P54132 | 1/20 | 0.84 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 2/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azathioprine SCHEMBL4252041 | 0.96 | MAPT (0.78) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL2328735 | 0.93 | MAPT (0.82) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL29693611 | 0.92 | MAPT (1.00) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL4436347 | 0.92 | MAPT (1.00) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL4278 | 0.92 | MAPT (1.00) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL26152 | 0.91 | MAPT (0.98) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL502599 | 0.91 | MAPT (0.98) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL317904 | 0.91 | MAPT (0.98) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL3089846 | 0.91 | MAPT (0.98) | MAPTHBBLMNAGMNNTP53 | |
| Azathioprine SCHEMBL2321074 | 0.84 | MAPT (0.70) | MAPTHBBLMNAGMNNTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306625-A1 | TREATMENT SYSTEMS AND METHODS FOR RENAL-RELATED DISEASES | ANGIODYNAMICS, INC. (US) | 2009-12-10 | — | — | US | disclosed |
| WO-2009114826-A2 | TREATMENT SYSTEMS AND METHODS FOR RENAL-RELATED DISEASES | ANGIODYNAMICS, INC. (US) | 2009-09-17 | — | — | WO | disclosed |