Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 7/20 | 0.34 |
| ▸ | RAF1 | P04049 | 4/20 | 0.34 |
| ▸ | BRAF | P15056 | 4/20 | 0.34 |
| ▸ | KRAS | P01116 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.34 |
| ▸ | ARAF | P10398 | 1/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30907087 | 0.90 | GSK3B (0.35) | GSK3BDYRK1AFGFR1SRCABL1 | |
| SCHEMBL30907335 | 0.84 | ABL1 (0.38) | GSK3BDYRK1AFGFR1SRCABL1 | |
| SCHEMBL30907378 | 0.83 | GSK3B (0.42) | GSK3BDYRK1AABL1MAP4K1IRAK4 | |
| SCHEMBL30907430 | 0.83 | ABL1 (0.34) | ABL1 | |
| SCHEMBL30907102 | 0.81 | FGFR1 (0.41) | FGFR1SRCABL1 | |
| SCHEMBL30907084 | 0.81 | GSK3B (0.36) | GSK3BDYRK1AFGFR1ABL1RAF1 | |
| SCHEMBL30907334 | 0.80 | ABL1 (0.46) | GSK3BDYRK1AABL1MAP4K1 | |
| SCHEMBL30907302 | 0.80 | MKNK2 (0.37) | GSK3BDYRK1AFGFR1SRCABL1 | |
| SCHEMBL24666550 | 0.79 | GSK3B (0.40) | GSK3BDYRK1AFGFR1SRCABL1 | |
| SCHEMBL30907294 | 0.78 | ABL1 (0.57) | GSK3BDYRK1AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024097953-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-05-10 | — | — | WO | disclosed |