Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3957044 | 0.98 | KDM4E (0.50) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL3955368 | 0.88 | MAPT (0.52) | KDM4EALDH1A1MAPTGLAGAA | |
| Bromide SCHEMBL5132009 | 0.87 | MAPT (0.51) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL3959035 | 0.85 | MAPT (0.60) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL890574 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL890546 | 0.84 | KDM4E (0.47) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL14627843 | 0.83 | MAPT (0.52) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL2715301 | 0.82 | MAPT (0.46) | KDM4EALDH1A1MAPTGLAGAA | |
| SCHEMBL3959722 | 0.81 | POLB (0.47) | KDM4EALDH1A1MAPTGLAGAA | |
| Bromide SCHEMBL3958091 | 0.81 | MAPT (0.43) | KDM4EALDH1A1MAPTGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799795-B2 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | AMGEN INC. (US) | 2010-09-21 | — | — | US | disclosed |
| US-7799795-B2 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | AMGEN INC. (US) | 2010-09-21 | — | — | US | disclosed |
| US-7799795-B2 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | AMGEN INC. (US) | 2010-09-21 | — | — | US | disclosed |
| EP-1917250-B1 | ANTI-INFLAMMATORY ARYL NITRILE COMPOUNDS | AMGEN INC (US) | 2010-07-21 | — | — | EP | disclosed |
| EP-1917250-B1 | ANTI-INFLAMMATORY ARYL NITRILE COMPOUNDS | AMGEN INC (US) | 2010-07-21 | — | — | EP | disclosed |
| US-20070015773-A1 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | AMGEN INC. | 2007-01-18 | — | — | US | disclosed |
| US-20070015773-A1 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | AMGEN INC. | 2007-01-18 | — | — | US | disclosed |
| US-20070015773-A1 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | AMGEN INC. | 2007-01-18 | — | — | US | disclosed |
| WO-2007002701-A2 | ANTI-INFLAMMATORY ARYL NITRILE COMPOUNDS | AMGEN INC. (US) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015773-A1 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | CCR1, MSR1, CCR2 | KDM4E 3102/4885ALDH1A1 742/4885MAPT 3387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.