Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30911402 | 0.74 | NT5E (0.33) | — | |
| SCHEMBL35211291 | 0.73 | MAT2A (0.34) | LRRK2PPARAKDM4EKMT2APOLB | |
| SCHEMBL25938589 | 0.63 | PPARA (0.39) | PPARAKDM4EKMT2APOLB | |
| SCHEMBL30911379 | 0.60 | NT5E (0.31) | — | |
| SCHEMBL21742934 | 0.60 | KDM5A (0.41) | KDM4EKMT2APOLB | |
| SCHEMBL25928277 | 0.60 | TLR9 (0.34) | PPARAKDM4EKMT2A | |
| SCHEMBL25938593 | 0.60 | PPARA (0.37) | PPARAKDM4EKMT2A | |
| SCHEMBL25928457 | 0.59 | JAK2 (0.36) | PPARAKDM4E | |
| SCHEMBL30911367 | 0.57 | CYP3A4 (0.31) | — | |
| SCHEMBL5564165 | 0.57 | ADORA2A (0.36) | LRRK2PPARAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024074977-A1 | SUBSTITUTED 1 H-PYRAZOLO-PYRIDINE AND-PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2024-04-11 | — | — | WO | disclosed |