Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21207106 | 1.00 | BRD4 (0.48) | BRD4NAMPTGAAL3MBTL1MAPT | |
| SCHEMBL20934709 | 0.79 | BCHE (0.48) | BRD4TDP1 | |
| SCHEMBL20763761 | 0.78 | PDCD1LG2 (0.46) | NAMPTGAA | |
| SCHEMBL30913765 | 0.76 | HRAS (0.66) | BRD4NAMPTL3MBTL1MAPTTDP1 | |
| SCHEMBL21207104 | 0.76 | HRAS (0.66) | BRD4NAMPTL3MBTL1MAPTTDP1 | |
| SCHEMBL2177544 | 0.75 | BRD4 (0.48) | BRD4NAMPTGAAL3MBTL1MAPT | |
| SCHEMBL3180689 | 0.74 | L3MBTL1 (0.61) | NAMPTGAAL3MBTL1MAPTTDP1 | |
| SCHEMBL27255820 | 0.74 | GAA (0.45) | NAMPTGAAL3MBTL1MAPTHDAC1 | |
| SCHEMBL31563705 | 0.74 | BRD4 (0.42) | BRD4NAMPTGAAL3MBTL1MAPT | |
| SCHEMBL32662613 | 0.74 | BRD4 (0.42) | BRD4NAMPTGAAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12024506-B2 | Compounds | THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) | 2024-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12024506-B2 | Compounds | KRAS, NRAS, HRAS | BRD4 731/4885NAMPT 3792/4885GAA 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.