Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.73 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.66 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.66 |
| ▸ | WEE1 | P30291 | 2/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.64 |
| ▸ | CDC7 | O00311 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27227953 | 1.00 | ULK1 (0.73) | ULK1PTK2PTK2BWEE1ALK | |
| SCHEMBL27228507 | 0.91 | ULK1 (0.61) | ULK1PTK2PTK2BWEE1ALK | |
| SCHEMBL30914277 | 0.91 | ULK1 (0.61) | ULK1PTK2PTK2BWEE1ALK | |
| SCHEMBL17547511 | 0.84 | ULK1 (1.00) | ULK1PTK2PTK2BWEE1ALK | |
| SCHEMBL27381488 | 0.82 | LRRK2 (0.53) | ULK1WEE1ALKLRRK2 | |
| SCHEMBL30861030 | 0.82 | LRRK2 (0.53) | ULK1WEE1ALKLRRK2 | |
| SCHEMBL3287523 | 0.81 | PTK2 (0.62) | ULK1PTK2PTK2BWEE1ALK | |
| SCHEMBL30861123 | 0.81 | LRRK2 (0.51) | ULK1LRRK2 | |
| SCHEMBL27373957 | 0.81 | LRRK2 (0.51) | ULK1LRRK2 | |
| SCHEMBL27380149 | 0.81 | LRRK2 (0.56) | ULK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240174647-A1 | KINASE MODULATORS AND METHODS OF USE THEREOF | NEURON23, INC. | 2024-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240174647-A1 | KINASE MODULATORS AND METHODS OF USE THEREOF | LRRK2, MAP3K20, MAP3K5 | ULK1 138/4885PTK2 155/4885PTK2B 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.