Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 17/20 | 0.61 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30919128 | 0.82 | DGAT2 (0.64) | DGAT2BACE1 | |
| SCHEMBL30919169 | 0.81 | DGAT2 (0.65) | DGAT2BACE1GABRA1 | |
| SCHEMBL30919040 | 0.80 | DGAT2 (0.66) | DGAT2BACE1KMT2A | |
| SCHEMBL30919235 | 0.80 | DGAT2 (0.59) | DGAT2BACE1 | |
| SCHEMBL30919156 | 0.78 | DGAT2 (0.66) | DGAT2 | |
| SCHEMBL30919054 | 0.78 | DGAT2 (0.74) | DGAT2 | |
| SCHEMBL30919192 | 0.78 | DGAT2 (0.78) | DGAT2 | |
| SCHEMBL30919075 | 0.77 | DGAT2 (0.77) | DGAT2 | |
| SCHEMBL30919113 | 0.77 | DGAT2 (0.77) | DGAT2 | |
| SCHEMBL30919096 | 0.76 | DGAT2 (0.56) | DGAT2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612151-A1 | PREPARATION OF IMIDAZOPYRIDINE AND IMIDAZOPYRIDAZINE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-09-10 | — | — | EP | claimed |
| WO-2024097573-A1 | PREPARATION OF IMIDAZOPYRIDINE AND IMIDAZOPYRIDAZINE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-05-10 | — | — | WO | claimed |
| EP-4612151-A1 | PREPARATION OF IMIDAZOPYRIDINE AND IMIDAZOPYRIDAZINE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024097573-A1 | PREPARATION OF IMIDAZOPYRIDINE AND IMIDAZOPYRIDAZINE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-05-10 | — | — | WO | disclosed |