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SCHEMBL30919940

SCHEMBL30919940

O=C1CCC(Nc2ccc(N3CCC(N4CCN(CCC(=O)Nc5cncc(Nc6ncc(Cl)c(-c7cccc(-c8ccccc8)c7)n6)c5)CC4)CC3)cc2)C(=O)N1

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ BTK Q06187 2/20 0.40
▸ JAK3 P52333 2/20 0.40
▸ JAK2 O60674 1/20 0.40
▸ JAK1 P23458 1/20 0.40
▸ PTK2 Q05397 8/20 0.40
▸ EGFR P00533 5/20 0.37
▸ ALK Q9UM73 1/20 0.37
▸ CRBN Q96SW2 3/20 0.37
▸ CDK13 Q14004 1/20 0.37
▸ CDK12 Q9NYV4 1/20 0.37
▸ DDB1 Q16531 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334997 0.86 MAPK1 (0.43) JAK3JAK2JAK1ALKCRBN
SCHEMBL27260491 0.83 ALK (0.33) BTKJAK3JAK2JAK1PTK2
SCHEMBL27259432 0.79 HDAC6 (0.40) BTKPTK2ALKCRBNCDK12
SCHEMBL31333897 0.78 MAPK1 (0.45) —
SCHEMBL27260388 0.77 MAPK1 (0.36) BTKALKCRBNDDB1
SCHEMBL30919845 0.77 MAPK1 (0.36) BTKALKCRBNDDB1
SCHEMBL31334848 0.75 MAPK1 (0.40) BTKJAK3JAK2JAK1CRBN
SCHEMBL27259667 0.75 PTK2 (0.53) PTK2EGFRCRBNCDK12
SCHEMBL27267210 0.74 PTK2 (0.53) PTK2EGFRCRBNCDK12
SCHEMBL27266440 0.74 PTK2 (0.53) PTK2EGFRCRBNCDK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4618755-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2025-09-24 — — EP disclosed
WO-2024107746-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES (US) 2024-05-23 — — WO disclosed