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Sugi Predict / Compounds / SCHEMBL31334848

SCHEMBL31334848

SCHEMBL31334848

O=C1CCC(Nc2ccc(N3CCC(N4CCC(C(=O)N[C@H]5CC[C@H](Nc6ncc(Cl)c(-c7cccc(-c8ccc(F)cc8)c7)n6)CC5)CC4)CC3)cc2)C(=O)N1

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 16/20 0.40
▸ JAK2 O60674 1/20 0.38
▸ JAK1 P23458 1/20 0.38
▸ JAK3 P52333 1/20 0.38
▸ DDB1 Q16531 2/20 0.38
▸ CRBN Q96SW2 2/20 0.38
▸ BTK Q06187 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333318 0.86 F10 (0.42) MAPK1JAK2JAK1JAK3
SCHEMBL31334587 0.84 ROCK1 (0.41) MAPK1JAK2JAK1JAK3
SCHEMBL31334459 0.83 CYP46A1 (0.39) MAPK1DDB1CRBNBTK
SCHEMBL31333797 0.82 MAPK1 (0.44) MAPK1
SCHEMBL31334904 0.81 PKM (0.47) MAPK1
SCHEMBL31333903 0.81 JAK2 (0.39) MAPK1JAK2JAK1JAK3DDB1
SCHEMBL31334997 0.81 MAPK1 (0.43) MAPK1JAK2JAK1JAK3CRBN
SCHEMBL31334982 0.81 CDK4 (0.38) JAK2JAK1JAK3DDB1CRBN
SCHEMBL31334716 0.79 DDB1 (0.35) MAPK1DDB1CRBN
SCHEMBL31334619 0.79 DDB1 (0.35) MAPK1DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 — — EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 — — WO disclosed