Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | DAO | P14920 | 1/20 | 0.52 |
| ▸ | DDO | Q99489 | 1/20 | 0.52 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29420757 | 0.82 | AHR (1.00) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL154593 | 0.82 | AHR (1.00) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL30462974 | 0.82 | HTT (0.61) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL14937732 | 0.82 | HTT (0.61) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL7162004 | 0.80 | HTT (0.59) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL13681192 | 0.80 | DAO (0.58) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL20258222 | 0.80 | HTT (0.59) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL3092106 | 0.80 | GAA (0.57) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL31563569 | 0.80 | HTT (0.59) | AHRHTTALDH1A1GAAKDM4E | |
| SCHEMBL5114407 | 0.80 | HTT (0.59) | AHRHTTALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367702-B2 | Quinolone derivative | ASTELLAS PHARMA INC. (JP) | 2013-02-05 | — | — | US | claimed |
| US-20100256113-A1 | QUINOLONE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-10-07 | — | — | US | claimed |
| EP-2194044-A1 | QUINOLONE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-06-09 | — | — | EP | claimed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069856-A1 | ANTIMALARIAL COMPOUNDS | LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2012-05-31 | — | — | WO | disclosed |
| EP-1364951-B1 | Triazoquinolone derivatives as pest controllers | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-05-02 | — | — | EP | disclosed |
| US-20070015773-A1 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | AMGEN INC. | 2007-01-18 | — | — | US | disclosed |
| EP-0407192-B1 | 4-Acyloxyquinoline derivatives and insecticidal or acaricidal compositions containing same | MEIJI SEIKA CO (JP) | 1997-03-05 | — | — | EP | disclosed |
| US-5444071-A | Hypotensive agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-08-22 | — | — | US | disclosed |
| EP-0412848-B1 | Quinoline derivatives, process for their preparation and their use as medicaments | ICI PLC (GB) | 1995-01-18 | — | — | EP | disclosed |
| US-5190952-A | 4-ACYLOXYQUINOLINE DERIVATIVES AND INSECTICIDAL OR ACARICIDAL COMPOSITIONS CONTAINING SAME | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1993-03-02 | — | — | US | disclosed |
| CN-1050187-A | New quinoline compound and preparation method thereof | ICI PLC (GB) | 1991-03-27 | — | — | CN | disclosed |
| EP-0412848-A2 | Quinoline derivatives, process for their preparation and their use as medicaments | ZENECA LIMITED (GB) | 1991-02-13 | — | — | EP | disclosed |
| EP-0407192-A2 | 4-Acyloxyquinoline derivatives and insecticidal or acaricidal compositions containing same | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1991-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015773-A1 | Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders | CCR1, MSR1, CCR2 | AHR 8/4885HTT 3311/4885ALDH1A1 742/4885 |
| US-20100256113-A1 | QUINOLONE DERIVATIVE | NQO1, NQO2, NADK | AHR 781/4885HTT 4209/4885ALDH1A1 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.