Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 12/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3095811 | 0.88 | MC4R (0.58) | MC4RMAPK1KCNH2 | |
| SCHEMBL3092179 | 0.86 | MC4R (0.49) | MC4RMAPK1MEN1HTTKMT2A | |
| SCHEMBL3095805 | 0.76 | MC4R (0.63) | MC4RPKM | |
| SCHEMBL14193882 | 0.75 | MC4R (0.49) | MC4RPKM | |
| SCHEMBL3095952 | 0.73 | MC4R (0.76) | MC4R | |
| SCHEMBL3095937 | 0.69 | MC4R (0.54) | MC4R | |
| SCHEMBL3093327 | 0.69 | MC4R (0.54) | MC4RKCNH2MEN1KMT2AALDH1A1 | |
| SCHEMBL13724512 | 0.67 | MC4R (0.51) | MC4RMAPK1MEN1HTTKMT2A | |
| SCHEMBL3088810 | 0.65 | MC4R (0.62) | MC4R | |
| SCHEMBL3077612 | 0.64 | MC4R (0.57) | MC4RMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790719-B2 | Modulators of melanocortin receptor | ORE PHARMACEUTICALS, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| EP-1590338-B1 | MODULATORS OF MELANOCORTIN RECEPTOR | ORE PHARMACEUTICALS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| US-7365070-B2 | Modulators of melanocortin receptor | ORE PHARMACEUTICALS INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-20070293498-A1 | Modulators of melanocortin receptor | GENE LOGIC, INC. (US) | 2007-12-20 | — | — | US | disclosed |
| EP-1590338-A2 | MODULATORS OF MELANOCORTIN RECEPTOR | Gene Logic Inc. (US) | 2005-11-02 | — | — | EP | disclosed |
| US-20040147746-A1 | Modulators of melanocortin receptor | MILLENNIUM PHARMACEUTICALS, INC. | 2004-07-29 | — | — | US | disclosed |
| WO-2004050610-A2 | MODULATORS OF MELANOCORTIN RECEPTOR | GENE LOGIC INC. (US) | 2004-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293498-A1 | Modulators of melanocortin receptor | MC4R, MC1R, MC5R | MC4R 1/4885MAPK1 833/4885KCNH2 3028/4885 |
| US-20040147746-A1 | Modulators of melanocortin receptor | MC1R, MC3R, MC5R | MC4R 4/4885MAPK1 610/4885KCNH2 3223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.