Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24536822 | 0.89 | KRAS (0.36) | KRAS | |
| SCHEMBL29679962 | 0.89 | KRAS (0.36) | KRAS | |
| SCHEMBL27191216 | 0.75 | KRAS (0.42) | KRAS | |
| SCHEMBL24535940 | 0.74 | KRAS (0.42) | KRAS | |
| SCHEMBL24535869 | 0.74 | KRAS (0.42) | KRAS | |
| SCHEMBL29680503 | 0.74 | KRAS (0.42) | KRAS | |
| SCHEMBL30229727 | 0.74 | KRAS (0.38) | KRAS | |
| SCHEMBL30707490 | 0.73 | KRAS (0.47) | KRAS | |
| SCHEMBL24536776 | 0.72 | KRAS (0.34) | KRAS | |
| SCHEMBL29680468 | 0.72 | KRAS (0.34) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598921-A1 | MACROCYCLIC KRAS INHIBITORS AND METHODS OF USE | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024107686-A1 | MACROCYCLIC KRAS INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2024-05-23 | — | — | WO | disclosed |