Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.64 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | NFATC1 | O95644 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | CPT1A | P50416 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3217902 | 1.00 | HASPIN (0.64) | HASPINPBRM1DYRK1AGSK3BNFATC1 | |
| SCHEMBL12481581 | 0.86 | HASPIN (0.64) | HASPINPBRM1CYP2C19KDM4EHSD17B10 | |
| SCHEMBL2052704 | 0.86 | DYRK1A (0.51) | HASPINDYRK1AGSK3BNFATC1CYP2D6 | |
| SCHEMBL30101234 | 0.86 | DYRK1A (0.51) | HASPINDYRK1AGSK3BNFATC1CYP2D6 | |
| SCHEMBL4357845 | 0.83 | ALDH1A1 (0.59) | HASPINDYRK1AGSK3BNFATC1CYP2D6 | |
| SCHEMBL22300127 | 0.83 | DYRK1A (0.49) | HASPINDYRK1AGSK3BNFATC1CYP2D6 | |
| SCHEMBL12480579 | 0.82 | CPT1A (0.48) | HASPINDYRK1AGSK3BNFATC1CYP2D6 | |
| SCHEMBL1607800 | 0.82 | NR4A2 (0.62) | HASPINDYRK1AGSK3BKDM4ECPT1A | |
| SCHEMBL31753965 | 0.82 | NR4A2 (0.62) | HASPINDYRK1AGSK3BKDM4ECPT1A | |
| SCHEMBL2628950 | 0.81 | CYP2D6 (0.48) | HASPINDYRK1AGSK3BNFATC1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118027028-A | AZ191 intermediate, preparation method and preparation method of AZ191 | 上海凌凯医药科技有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-118027028-A | AZ191 intermediate, preparation method and preparation method of AZ191 | 上海凌凯医药科技有限公司 | 2024-05-14 | — | — | CN | disclosed |