Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19616 | 0.83 | CYP2C19 (0.32) | — | |
| Acetic Acid SCHEMBL20746004 | 0.80 | — | — | |
| SCHEMBL9568683 | 0.76 | LMNA (0.40) | LMNA | |
| SCHEMBL2771351 | 0.73 | LMNA (0.37) | LMNA | |
| SCHEMBL31337 | 0.70 | LMNA (0.32) | LMNA | |
| SCHEMBL12605383 | 0.69 | — | — | |
| SCHEMBL15135616 | 0.69 | — | — | |
| SCHEMBL9790493 | 0.69 | LMNA (0.33) | LMNA | |
| SCHEMBL16478350 | 0.67 | LMNA (0.33) | LMNA | |
| SCHEMBL19135 | 0.67 | LMNA (0.34) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608669-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |