⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293819 | 0.84 | — | — | |
| SCHEMBL292600 | 0.76 | — | — | |
| SCHEMBL5762699 | 0.74 | — | — | |
| SCHEMBL866049 | 0.71 | — | — | |
| SCHEMBL75552 | 0.59 | — | — | |
| SCHEMBL458291 | 0.59 | — | — | |
| SCHEMBL250800 | 0.59 | — | — | |
| Hydrochloric Acid SCHEMBL11584271 | 0.57 | — | — | |
| SCHEMBL2432991 | 0.56 | — | — | |
| SCHEMBL775375 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181966-A1 | PGD2 receptor antagonists for the treatment of inflammatory diseases | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-16 | — | — | US | claimed |
| EP-1740547-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-01-10 | — | — | EP | claimed |
| US-20050256158-A1 | PGD2 receptor antagonists for the treatment of inflammatory diseases | MILLENNIUM PHARMACEUTICALS, INC. | 2005-11-17 | — | — | US | claimed |
| WO-2005100321-A1 | PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-27 | — | — | WO | claimed |
| CN-109431996-B | Minoxidil-containing external preparation composition and preparation method thereof | 浙江万晟药业有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-109431996-A | A kind of preparation composition for external use and preparation method thereof containing minoxidil | 杭州新博思生物医药有限公司 | 2019-03-08 | — | — | CN | disclosed |
| US-20150105386-A1 | 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS | ABBVIE DEUTSCHLAND (DE) | 2015-04-16 | — | — | US | disclosed |
| US-8895749-B2 | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators | ABBVIE INC. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20130310378-A1 | 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS | ABBVIE INC. (US) | 2013-11-21 | — | — | US | disclosed |
| US-8507546-B2 | Use of inhibitors of scavenger receptor class proteins for the treatment of infectious diseases | INSTITUTO DE MEDICINA MOLECULAR, FACULDADE DE MEDICINA DA UNIVERSIDADE DE LISBOA (PT) | 2013-08-13 | — | — | US | disclosed |
| US-8445686-B2 | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators | ABBVIE INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20120276121-A1 | USE OF INHIBITORS OF SCAVENGER RECEPTOR CLASS PROTEINS FOR THE TREATMENT OF INFECTIOUS DISEASES | INSTITUTO DE MEDICINA MOLECULAR, FACULDADE DE MEDICINA DA UNIVERSIDADE DE LISBOA (PT) | 2012-11-01 | — | — | US | disclosed |
| EP-0650358-A1 | 17-ACYL-4-AZA-STEROID-3-ONE AS 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-05-03 | — | — | EP | disclosed |
| EP-0641205-A4 | 17-g(a) AND 17-g(b) SUBSTITUTED ACYL 4 AZA STEROIDS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0641205-A1 | 17$g(a) AND 17$g(b) SUBSTITUTED ACYL 4 AZA STEROIDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1995005821-A1 | DI- AND TETRA-HYDROBENZO[F]QUINOLIN-3-ONES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-03-02 | — | — | WO | disclosed |
| EP-0638090-A1 | 17$g(a) AND 17$g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID | SMITHKLINE BEECHAM CORPORATION (US) | 1995-02-15 | — | — | EP | disclosed |
| WO-1994017663-A1 | TREATING ALOPECIA BY ADMINISTERING 5-ALPHA-REDUCTASE INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-08-18 | — | — | WO | disclosed |
| WO-1994011004-A1 | 17 SUBSTITUTED ACYL-3-CARBOXY 3,5-DIENE STEROIDALS AS 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |
| WO-1994011386-A1 | 17-ALPHA AND 17-BETA SUBSTITUTED ACYL-3-CARBOXY-3,5-DIENES AND USE IN INHIBITING 5-ALPHA-REDUCTASE | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |