Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24596437 | 0.79 | GRIN1 (0.55) | GRIN1GRIN2AOPRM1DRD4ALDH1A1 | |
| SCHEMBL28760658 | 0.79 | GRIN1 (0.55) | GRIN1GRIN2AOPRM1DRD4ALDH1A1 | |
| SCHEMBL18408950 | 0.77 | ADRA1B (0.46) | GRIN1GRIN2AOPRM1BACE1BACE2 | |
| SCHEMBL21560581 | 0.75 | GRIN1 (0.42) | GRIN1GRIN2AOPRM1DRD4ALDH1A1 | |
| SCHEMBL2310052 | 0.74 | ADRA1B (0.40) | GRIN1GRIN2AOPRM1DRD4ALDH1A1 | |
| SCHEMBL2312275 | 0.74 | ADRA1B (0.42) | GRIN1GRIN2AOPRM1ALDH1A1MEN1 | |
| SCHEMBL20714377 | 0.74 | GRIN1 (0.50) | GRIN1GRIN2AOPRM1DRD4ALDH1A1 | |
| SCHEMBL14476973 | 0.73 | GRIN1 (1.00) | GRIN1GRIN2AOPRM1DRD4MEN1 | |
| SCHEMBL2310569 | 0.70 | CYP2D6 (0.46) | ALDH1A1CYP2C9KMT2AHSD11B1CYP2D6 | |
| SCHEMBL2309924 | 0.70 | ADRA1B (0.42) | GRIN1GRIN2AOPRM1MEN1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4617265-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Prime Gene Therapeutics Co., Ltd. (CN) | 2025-09-17 | — | — | EP | disclosed |
| CN-120202197-A | Nitrogen-containing spiro compound, pharmaceutical composition and application thereof | 北京普祺医药科技股份有限公司 | 2025-06-24 | — | — | CN | disclosed |
| WO-2024099404-A1 | NITROGEN-CONTAINING SPIROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 北京普祺医药科技股份有限公司 | 2024-05-16 | — | — | WO | disclosed |