Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.65 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23066372 | 1.00 | ROCK2 (0.65) | ROCK2ROCK1MYLK4TNF | |
| SCHEMBL173486 | 0.93 | ROCK2 (0.75) | ROCK2ROCK1MYLK4TNF | |
| SCHEMBL174353 | 0.93 | ROCK2 (0.75) | ROCK2ROCK1MYLK4TNF | |
| SCHEMBL112454 | 0.93 | ROCK2 (0.75) | ROCK2ROCK1MYLK4TNF | |
| SCHEMBL23066423 | 0.87 | ROCK2 (0.65) | ROCK2ROCK1MYLK4 | |
| Netarsudil SCHEMBL30934339 | 0.86 | ROCK2 (0.85) | ROCK2ROCK1MYLK4 | |
| Netarsudil SCHEMBL23066367 | 0.86 | ROCK2 (0.85) | ROCK2ROCK1MYLK4 | |
| Netarsudil SCHEMBL23066391 | 0.86 | ROCK2 (0.76) | ROCK2ROCK1MYLK4 | |
| SCHEMBL18827679 | 0.86 | ROCK2 (0.73) | ROCK2ROCK1MYLK4TNF | |
| Netarsudil SCHEMBL23066437 | 0.85 | ROCK2 (0.76) | ROCK2ROCK1MYLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768661-B1 | DEUTERATED COMPOUNDS AS ROCK INHIBITORS | FOCHON PHARMACEUTICALS LTD (CN) | 2024-05-01 | — | — | EP | disclosed |