Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 9/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16097051 | 1.00 | HIF1A (0.43) | HIF1AEGFRKDRDGAT1HTT | |
| SCHEMBL17368525 | 0.89 | HIF1A (0.46) | HIF1AEGFRKDRDGAT1HTT | |
| SCHEMBL16100893 | 0.88 | EGFR (0.45) | HIF1AEGFRKDRDGAT1MAPKAPK2 | |
| SCHEMBL30935135 | 0.88 | EGFR (0.45) | HIF1AEGFRKDRDGAT1MAPKAPK2 | |
| SCHEMBL16101030 | 0.87 | HIF1A (0.43) | HIF1ADGAT1KMT2AALDH1A1 | |
| SCHEMBL30380339 | 0.87 | HIF1A (0.43) | HIF1ADGAT1KMT2AALDH1A1 | |
| SCHEMBL16097189 | 0.86 | HIF1A (0.43) | HIF1AEGFRKDRDGAT1 | |
| SCHEMBL16123331 | 0.82 | DGAT1 (0.41) | HIF1AEGFRKDRDGAT1MAPKAPK2 | |
| SCHEMBL16101389 | 0.82 | AAK1 (0.45) | HIF1AEGFRKDRDGAT1ITK | |
| SCHEMBL16101102 | 0.81 | HIF1A (0.40) | HIF1AEGFRKDRDGAT1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125464-A1 | TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-20 | — | — | WO | disclosed |