Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 6/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935046 | 1.00 | RORC (0.39) | RORCCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL31694008 | 0.90 | RORC (0.39) | RORCCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL691049 | 0.85 | NR1H2 (0.42) | USP30KDM1AGPR183NR1H2SIRT2 | |
| SCHEMBL30935244 | 0.83 | KDM1A (0.33) | KDM1AGPR183NR1H2SIRT2SIRT1 | |
| SCHEMBL31693945 | 0.83 | USP30 (0.34) | RORCCCNB2CDK1CCNB1GSK3B | |
| SCHEMBL446546 | 0.82 | MAPT (0.45) | SIRT2 | |
| SCHEMBL30935273 | 0.81 | USP30 (0.41) | USP30BACE1KDM1AGPR183NR1H2 | |
| SCHEMBL25245307 | 0.79 | NR1H2 (0.37) | RORCUSP30BACE1KDM1AABHD6 | |
| SCHEMBL18322102 | 0.79 | NR1H2 (0.49) | RORCUSP30IDO1GPR183ABHD6 | |
| SCHEMBL29404795 | 0.79 | NR1H2 (0.49) | RORCUSP30IDO1GPR183ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125464-A1 | TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-20 | — | — | WO | disclosed |