Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.55 |
| ▸ | DUT | P33316 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TK2 | O00142 | 8/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.35 |
| ▸ | TK1 | P04183 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275984 | 0.83 | KIF11 (0.74) | KIF11DUTHRH4TK2TSHR | |
| SCHEMBL29824618 | 0.78 | KIF11 (0.57) | KIF11DUTHRH4TK2TSHR | |
| SCHEMBL17297687 | 0.78 | KIF11 (0.61) | KIF11DUTHRH4TK2TSHR | |
| SCHEMBL26176887 | 0.77 | KIF11 (0.65) | KIF11DUTHRH4MEN1LMNA | |
| SCHEMBL26176905 | 0.77 | KIF11 (0.65) | KIF11DUTHRH4MEN1LMNA | |
| SCHEMBL26176899 | 0.77 | KIF11 (0.65) | KIF11DUTHRH4MEN1LMNA | |
| SCHEMBL26176885 | 0.77 | KIF11 (0.65) | KIF11DUTHRH4MEN1LMNA | |
| SCHEMBL26176886 | 0.77 | KIF11 (0.65) | KIF11DUTHRH4MEN1LMNA | |
| SCHEMBL31430932 | 0.77 | KIF11 (0.65) | KIF11DUTHRH4MEN1LMNA | |
| SCHEMBL26176912 | 0.77 | KIF11 (0.65) | KIF11DUTHRH4MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |