Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14738548 | 0.89 | TGFBR1 (0.48) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL14750976 | 0.88 | TGFBR1 (0.52) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL30935710 | 0.83 | GAA (0.46) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL5030840 | 0.82 | TGFBR1 (0.53) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL14739441 | 0.81 | TGFBR1 (0.54) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL30935525 | 0.81 | TGFBR1 (0.42) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL30935695 | 0.80 | TGFBR1 (0.51) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL14740009 | 0.80 | TGFBR1 (0.47) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL27077008 | 0.79 | TGFBR1 (0.50) | TGFBR1GAAKDM4EGLAPIK3CD | |
| SCHEMBL22940953 | 0.78 | TGFBR1 (0.52) | TGFBR1GAAKDM4EGLAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |