Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 16/20 | 0.77 |
| ▸ | CA2 | P00918 | 16/20 | 0.77 |
| ▸ | CA12 | O43570 | 15/20 | 0.77 |
| ▸ | CA9 | Q16790 | 15/20 | 0.77 |
| ▸ | CA7 | P43166 | 3/20 | 0.77 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.62 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.58 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.58 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.58 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.58 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.58 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.58 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.58 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10603454 | 0.87 | CA1 (1.00) | CA1CA2CA12CA9CA7 | |
| SCHEMBL19948482 | 0.85 | CA1 (0.72) | CA1CA2CA12CA9CA7 | |
| SCHEMBL28499329 | 0.81 | KMT2A (1.00) | CA1CA2CA12CA9CA7 | |
| SCHEMBL23086242 | 0.79 | CA2 (0.87) | CA1CA2CA12CA9CA7 | |
| SCHEMBL6252334 | 0.78 | KMT2A (1.00) | CA1CA2CA12CA9CA7 | |
| SCHEMBL9280164 | 0.77 | PTPN7 (1.00) | CA1CA2CA12CA9CA7 | |
| SCHEMBL28585561 | 0.76 | CA2 (0.69) | CA1CA2CA12CA9CA7 | |
| SCHEMBL420453 | 0.76 | MAPT (0.66) | CA1CA2CA12CA9CA7 | |
| SCHEMBL28959793 | 0.76 | KMT2A (0.79) | CA1CA2CA12CA9CA7 | |
| SCHEMBL20851320 | 0.75 | CA1 (0.71) | CA1CA2CA12CA9CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119365196-A | Methods of treating solid tumors using heteroaromatic macrocyclic ether compounds | 纽威伦特公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-118234725-A | Solid forms of heteroaromatic macrocyclic ether compounds, pharmaceutical compositions and preparation thereof | 纽威伦特公司 | 2024-06-21 | — | — | CN | disclosed |